Pymetrozine insecticide

Pymetrozine is a pyridine heterocyclic insecticide, which is highly efficient, low-toxic, environmentally friendly, and accords with the current development direction of pesticides. The insecticide has a unique mode of action, has no knockdown activity, and does not produce direct toxicity to the insects, but once insects come into contact with the agent, they immediately stop feeding. Researchers at Dalian University of Technology used ethyl acetate as the starting material, followed by six steps of the hydrolysis and esterification of esters, alkylation of amines, condensation of ketones and hydrazines, hydrolysis of amides, and condensation of amines and aldehydes. A novel and efficient pesticide pymetrozine was synthesized with a total yield of 52.9%. The liquid phase analysis showed that the product purity was 99.95%. According to researchers, even if resistance to organophosphorus and carbamate insecticides has developed, pymetrozine has unique control effects against sucking mouthpart insects, especially aphids, whiteflies, and black-tailed leafhoppers. Can be used for the control of various resistant strains of pests. Due to its high selectivity, low toxicity to mammals, and safety to birds, fish, and non-target arthropods, it shows good prospects for development in comprehensive prevention and control.

Tadalafil Intermediates are Intermediates of tadalafil.
Tadalafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia (BPH). It is in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors that also includes sildenafil (Viagra) and vardenafil (Levitra). Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. 

Tadalafil Intermediates

Tadalafil Intermediates,Tadalafil Intermediate Aphrodisiac Drug,Tadalafil Intermediate Chloropretadalafil,Tadalafil N-1 Powder Erectile Dysfunction

Jinan Jianfeng Chemical Co., Ltd. , http://www.pharmachemm.com