The pharmacokinetics of Andrographis paniculata
Pharmacokinetics In vivo: After intravenous administration of 35S-labeled andrographolide sodium bisulfite adduct to rats, the blood concentration drops rapidly and can rapidly appear through the blood-brain barrier in various parts of the central nervous system. The highest; in the distribution of various organs, the highest degree of kidney accumulation was at 2 hours after injection, and the highest degree of rectal accumulation was at 6 hours after injection. The main form was excreted from urine, and the biological half-life was 2 hours. After intravenous injection of 35S-labeled andrographolide sodium bisulfite adduct into rats, the blood content decreased rapidly and could rapidly appear through the blood-brain barrier in various parts of the central nervous system, with the highest content in the spinal cord. Obvious downward positioning. The kidneys were the highest for all organs, and the rectum was highest after 6 hours. Mainly excreted by the original urine quickly. Experiments with 3H-andrographolide in mice showed that when 0.33 mg was intravenously injected into each mouse, 3H-andrographolide was rapidly distributed in mice, but the elimination was slower and the distribution rate constant a was 0.189 minutes. The rate constant B is 0.0026 minutes. Each mouse was intragastrically administrated with 0.66 mg, and the distribution of absorption was very rapid. It reached a peak at 30.75 minutes, peak blood concentration was 16 μg/ml, and utilization rate was 44.06%. After the drug breaks up, it quickly enters the organs, and the stomach and small intestine take 30 minutes. The remaining organs reach the highest concentration in 60 minutes. The radioactivity in the gallbladder, stomach, liver, and small intestine is the strongest. The uterus, kidney, ovary, and lungs are the second highest. The rectum, spleen, heart, and brain are lower. Since then, the radioactivity of various organs gradually decreased, but at 48 hours, the organs still had some radioactivity. At this time, each of the corresponding peak concentrations was 11.1%, 5.6%, 14.9% spleen, 10.9% spleen, and 7.9% kidney respectively. The brain was 20.9%, the small intestine was 3.2%, the rectum was 8.6%, the uterus was 5.1%, and the ovaries were 5.1%. Twenty-four hours after intragastric administration, 89.7% of urine was excreted from the urine, and 94.25% was discharged within 48 hours, of which urine was 48.97% and feces was 45.28%. A thin layer analysis of urine and liver revealed that 3H-andrographolide contained only 11% and 10%, and the remaining 87% (urine) or 77% (liver) were fat-soluble substances formed after metabolism. The drug-time curve after dehydration andrographolide disodium monosuccinate monopotassium salt (DASK) 100 mg/kg after intravenous administration was in line with the open two-compartment model, and the distribution phase was very short. The drug-time curve obtained after intramuscular injection of 150 mg/kg was in line with the one-compartment model. Absorption was faster and more complete, and only 24.9±18.1% of DASK urine was discharged within 24 hours after intramuscular injection. Organic inulin powder is a natural food source of prebiotic soluble fibers. Inulin is a soluble fiber naturally found in many fruits and vegetables like bananas, asparagus, garlic, onions, and more. Our inulin is extracted from the Jerusalem artichoke rhizome. We extracted the inulin by water extraction, ion exchange, membrane filtration, and spray drying, and other processes.
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