Scientists discover new ways of fat burning

Scientists discover new ways of fat burning

July 31, 2018 Source: China Science News Author: Lu also

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According to a recent paper published in Nature, the metabolite succinic acid can affect the body temperature, energy consumption and weight of mice through a previously unrecognized thermoregulatory pathway.

Energy intake greater than consumption often leads to obesity. In general, there are two main ways to lose weight: one is to reduce food intake, reduce the amount of heat that needs to be metabolized; the other is to burn more calories through exercise and other means. Heat is also the "fuel" needed for beige and brown fat. Unlike white fat, which is good at storing energy and easily accumulating in obesity, beige and brown fat cells contain large amounts of mitochondria, which also generate heat during the different formation of energy molecules. For mammals, beige and brown fats play a very important role in regulating body temperature and keeping warm. The mitochondrial heat production process also burns calories, but studies have shown that it is difficult to activate beige and brown fat on demand.

Edward Chouchani of the Dana-Farber Cancer Institute in Massachusetts, USA, and colleagues screened for metabolites that were high in brown fat and increased in low-temperature environments, and finally screened out the intermediates that released the process of storing energy— Succinate (succinate). When muscle activity is trembling, succinic acid is released into the blood and is absorbed by beige and brown fat cells. The researchers found that succinic acid can increase the local temperature of beige and brown fat in mice; by drinking water mixed with succinic acid, mice fed high-fat diets successfully avoided obesity.

Joshua Rabinowitz of Princeton University in New Jersey and others pointed out in a related article that further verification of whether succinic acid can also promote fat burning in human body would be very meaningful, and emphasized that the difference between mice and humans lies in the brown body. It is relatively small with beige fat and decreases with age. The researchers therefore caution that this difference may limit the extent to which calorie consumption is altered by activating the brown fat metabolism process. (Lu Yi)

Related paper information: DOI: 10.1038/s41586-018-0353-2

Chinese Journal of Science and Technology (2018-07-31 2nd Edition International)

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