Baricitinib CAS No. 1187594-09-7

  • Model NO.: 1187594-09-7
  • Customized: Non-Customized
  • Suitable for: Elderly, Adult
  • Purity: >99%
  • Mf: C25h24n6o2
  • Trademark: YC
  • Specification: ISO9001: 2008
  • HS Code: 3001909099
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001, USP, BP
  • State: Solid
  • CAS: 936563-96-1
  • MW: 440.5
  • Transport Package: Foil Bag/Tin or as Your Request
  • Origin: China
    
CAS No.1187594-09-7
Chemical Name:Baricitinib
SynonymsLY 3009104;INCB 028050;Baricitinib;Baricitinib, >=98%;Baricitinib (LY3009104);Baricitinib(INCB 028050;Baricitinib Chemical Structure;Baricitinib/INCB 028050/LY3009104;aricitinib (LY3009104, INCB028050);Baricitinib (LY3009104, INCB028050)
CBNumber:CB82620596
Molecular Formula:C16H17N7O2S
Formula Weight:371.41688

Description
Baricitinib is known as 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile chemically, which is a orally administrated inhibitor of Janus kinase 1 and 2 (JAK1/2) (a key enzyme involved in cytokine signaling, inflammation and immune function). It has certain anti-inflammatory, immunomodulating and antineoplastic activities. It takes effect through directly biding to JAK1/2, inhibiting the JAK1/2 activation and further inhibiting the JAK-signal transducers and activators of transcription (STAT) signaling pathway. As a consequence, the production of the inflammatory cytokines is reduced and the inflammatory response is inhibited. It can also induce apoptosis and inhibit the growth of related tumor cells. Phase II and phase III have confirmed its efficacy for treatment of rheumatoid arthritis.

Uses
Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.


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Baricitinib CAS No. 1187594-09-7
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