New research reveals a new mechanism for Zika virus outbreaks

On January 31, a research team led by Chinese scholars published a report in the British journal Nature Communications on the 29th that they discovered a new mechanism for the outbreak of Zika virus, due to mutations in viral sites. The ability of the virus to inhibit the natural immune defense of the animal host is enhanced, thereby also enhancing the ability of the virus to infect the human body as well as pathogenicity.
Zika virus is mainly transmitted by mosquito bites. The team led by Prof. Shi Peiyong from the University of Texas Medical Division, Galveston Campus, conducted an in-depth analysis of the causes of the large-scale outbreak of Zika virus.
Zika virus is divided into two plant types during the evolution process, namely African strain and Asian strain. Since the beginning of 2015, the Zika epidemic in Brazil and other American countries has been dominated by Asian strain viruses. In an interview with Xinhua News Agency reporters, Shi Peiyong said that by comparing the Asian and African strains of Zika virus, they found that a site mutation on the NS1 protein of the Asian strain of Zika virus effectively inhibited the production of an interferon in the host, making the virus Successful escape from the host's natural immunity, enhance the ability of the virus to replicate and infect in the human body. This provides a new scientific basis for explaining the large-scale outbreak of Zika virus in recent years.
Dr. Xia Hongjie, the first author of the report and the University of Texas Medical Division, Galveston, said that the Zika virus has undergone an unprecedented evolution in the process of transmission, especially in recent years, which has enhanced the ability of the virus to infect, causing widespread epidemics and outbreaks. .
Since 2015, Zika virus has continued to spread in countries such as Brazil. People may develop symptoms such as fever, rash, and joint pain after infection with Zika virus. The majority of Zika virus infections have mild symptoms, but pregnant women infected with Zika virus may damage the fetal brain, leading to defects such as neonatal small head disease.

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