Scientists start to search for scientific basis for raspberry to prevent liver cancer

In recent years, reports on the prevention of cancer by vegetables and fruits have been widely reported in the media, but the explanation of the mechanism of preventing cancer in vegetables and fruits is not clear.

In 2007, the National Natural Science Foundation of China, the professor of the Fourth Affiliated Hospital of Harbin Medical University, applied for the approval of the National Natural Science Foundation of China. The mechanism of the prevention of liver cancer by raspberry was studied.

During his postdoctoral research at Cornell University in the US, Liu Ming conducted an in-depth experimental study of the anti-tumor mechanisms of natural fruit extracts. After returning home, he continued to conduct relevant research in this direction. For the first time, he proposed that fruit extracts have "anti-tumor mechanism" of antioxidation, inhibition of tumor cell proliferation and neovascularization.

According to reports, the death rate of malignancies in China is increasing by 1.8% every year, and the incidence rate is increasing by 2.5% per year. The rate of increase in malignant tumors in rural areas is significantly higher than that in cities. Children and children mainly suffer from leukemia and brain tumors, accounting for 38% and 21% of all childhood cancers. The incidence and death rate of cancer in our country has been showing a clear upward trend, and it has become the leading cause of death among urban residents. However, among the cancer patients attending the clinic, the early cases were less than 10%. Therefore, we should let the people understand more about cancer and try to prevent, diagnose and treat as early as possible.

Liu Ming said that the occurrence of cancer can be roughly divided into three stages: First, the DNA of genetic material of normal cells is damaged, and the genetic factors of cancer are “awakened”; the second is the acceleration of cell division and the addition of canceration; the third is the deterioration of cancer. Began to transfer. Many plant foods contain important biologically active trace substances such as flavonoids, phytosterols, and phytoestrogens. These compounds have highly effective inhibitory effects on three stages of cancer.

Liu Ming’s current fund project is mainly to study the mechanism of action of raspberry extracts in preventing liver cancer through animal models and in vitro experiments.

He said: “The reason why liver cancer was chosen as the research object is because liver cancer is called the king of cancer. Although the current diagnostic and therapeutic levels are very advanced, once it has liver cancer, the long-term effects and survival of the treatment should not be tolerated. Optimistic.China is also a country with high incidence of liver diseases, with a large number of carriers of hepatitis B virus, long-term consumption of moldy food in rural areas, and high-risk groups of people with a history of family history of liver cancer.In our country, liver cancer is not only a medical problem, but also a Social problems. The most economical way to solve this problem is to advance the defense line, which is to prevent the formation of liver cancer."

The raspberry is one of the third-generation fruit that has emerged in recent years at home and abroad. It is known as “gold fruit” in the world, and it is rich in a large amount of deuterated acid, which can effectively inhibit tumor growth. "In my previous research, it has been found that raspberries can effectively inhibit the growth of liver cancer cells in vitro," Liu Ming explained further.

The prevention of liver cancer by raspberry is a synergistic effect of a variety of phytochemicals, but the specific process of the current role has not been clearly resolved. Liu Ming stated that his research group will use aflatoxin as a carcinogen in the next step to quickly form an animal model of primary liver cancer in a short period of time, and then use raspberry extract for oral administration to observe raspberry extracts for Prevent the prevention of aflatoxin-induced liver cancer. In addition, proteomics research is also required. Liu Ming believes that no matter what kind of intervention agent, it will eventually interfere with the body's metabolism. They hope to find specific targets for the action of raspberry extracts and lay the foundation for accurate targeted therapy in the future.

Liu Ming said that they had hoped to carry out human experiments, but due to limited funding, they cannot be carried out yet. In fact, the human experiment of the prevention of liver cancer by raspberry is relatively good, because it does not have ethical issues, just let the experimental subjects eat fruit, there is no toxic side effects. "We are seeking cooperation from relevant parties."

Liu Ming further explained: “Of course, human experimentation is a long-term process that requires a lot of time and effort. However, if human experiments can achieve good results, it will provide a new idea for the prevention and treatment of liver cancer in China. ”

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