"Virtual Patient" simulates real-time organ movement for radiation therapy

Release date: 2008-04-22

"Virtual Patient" Simulates Real-Time Organ Movement for Radiation Therapy The National Institutes of Health (NIH) approved a grant of $2 million from a researcher at Rensselaer Polytechnic Institute to develop a model of real-time virtual patient breathing using applied physics, or 3D The model combined with the time variable obtained by the 4D model, its application can significantly improve the accuracy and effectiveness of lung cancer and liver cancer radiotherapy. At the Cancer Treatment and Research Center in St. Anthony, Texas, George Xu (Professor of Biomedical Engineering and Nuclear Medicine) and Suvranu De (Associate Professor of Mechanical Engineering) collaborate with colleagues in clinical practice to develop 4D visualization Image person (4-D VIP-Man). This virtual model is an extension of Professor Xu's ongoing 3-D VIP-Man program. This project is an advanced computer model that uses 3-D technology to simulate how radiation affects the body's organs and tissues. Professor Xu believes that living people are different from still creatures, and in radiotherapy and imaging of tumors, organs that can move like lungs or heart are the main interfering factors. In order to determine the effective radiometry and its exact value, doctors must consider issues such as respiratory movements and changes in air volume, which are affected by physiological factors during radiotherapy. Real-time simulation enables doctors to observe that the lungs, liver, kidneys, and heart are stationary relative to the external ray in a short period of time. In clinical treatment, doing this means that doctors are more confident in radiotherapy for sports tumors. 4-D VIP-Man allows doctors and medical physicists to accurately predict and monitor these anatomical changes to provide the most effective treatment at all times. But 4-D VIP-Man is difficult to develop. Professor Xu and Associate De are now focusing on breathing. It is feasible to simulate lung movement using advanced computer technology; however, real-time simulation cannot be achieved. For precision radiotherapy, the application of physical technology real-time virtual human functions can ultimately solve this problem. The main difficulty of this program is how to develop the corresponding algorithm to simulate the movement of the lungs and adjacent tissues in real time according to the real biomechanical properties of the organization. Professor Xu predicts that the physics-based 4-D VIP-Man will eventually be used more widely as an anatomical model in the biomedical field to help treat patients with respiratory diseases and heart disease. At the same time, he will continue to study 3-D VIP-Man and create a “family spectrum” of virtual patients through the Computer Imaging Human Imaging Association (http://) in collaboration with researchers around the world. Professor Xu's former students Chengyu Shi (clinical medical physicist) and Martin Fuss (radiation oncologist) believe that radiotherapy will be better after solving lung movement problems. After learning about their interests, Xu and the Tennessee research team began working together. The idea of ​​improving 3-D VIP-Man to 4-D VIP-Man was made after contacting Associate Professor De (who had used 3-D VIP-Man technology to simulate tissue deformation during surgery). Since 1997, Xu has been working on the previous Visible Human Project to study 3-D VIP-Man, the dataset from the National Library of Medicine, funded by NIH and the National Science Foundation. Will CAREER bonus. The new four-year research fund is funded by the National Library of Medicine (part of the NIH). ——Midi Medical Network

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