U.S. develops new technology to accelerate bone growth
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Researchers at the University of California, San Diego have developed a new way to accelerate bone growth based on titanium oxide nanotubes to grow stem cells, which can lay the foundation for faster and better recovery of orthopedic patients.
This study is the first to associate stem cells with titanium oxide nanotube implants. The researchers used nano-biotechnology to place human mesenchymal stem cells on ultra-thin titanium oxide nanotubes to control the differentiation pathway of cells and become osteoblasts or osteoblasts. Human mesenchymal stem cells differ from embryonic stem cells and can be directly extracted from the patient's own bone marrow.
Researchers say that if people accidentally break their knees or legs during skiing, the orthopaedic surgeon will implant a titanium rod for them, and the patient will be with the crutches in the next 3 months. By combining stem cells with titanium oxide nanotubes, it is expected to significantly increase the healing rate of patients, and patients can resume walking within one month.
According to relevant data, implant treatment with titanium oxide nanotubes can effectively reduce bone loosening. This is one of the main problems in orthopedic treatment. Once loosening occurs, the implant needs to be re-operated. There is great health risk and inconvenience for elderly patients, which is not desirable from the perspective of cost. .
Researchers believe that controlling the exact change in nanotube diameter can lead to the selective conversion of stem cells to osteoblasts. Larger diameter nanotubes are more conducive to the growth of cells on their surface, thus achieving faster and better bone growth. Previous studies have often been based on the surface culture of chemicals to control cell differentiation. However, the implantation of chemicals into the body is prone to side effects. It is not an ideal choice for implant materials. The use of nanomaterials instead of chemicals can reduce the body's adverse reactions.
The research team will then work with orthopaedic specialists at the same school to apply this breakthrough to the clinic to benefit more patients.
——Shanghai Medical Device Industry Association